What is the FDA-approved tirzepatide dosing schedule?

Tirzepatide titrates over 20 weeks through six dose levels: 2.5mg (weeks 1–4), 5mg (weeks 5–8), 7.5mg (weeks 9–12), 10mg (weeks 13–16), 12.5mg (weeks 17–20), then 15mg maintenance. Each step lasts 4 weeks to reach steady-state and minimize GI side effects.

What happens if I miss a tirzepatide dose?

If within 4 days (96 hours) of the missed dose, take it as soon as you remember then resume your regular schedule. If more than 4 days have passed, skip it and take the next dose on the regular day. Never take two doses within 3 days of each other.

What happens when I stop taking tirzepatide?

The SURMOUNT-4 trial showed patients who stopped tirzepatide after 36 weeks regained approximately two-thirds of their lost weight over the following 52 weeks. Obesity is a chronic condition requiring ongoing treatment; discuss a gradual dose-reduction plan with your prescriber rather than stopping abruptly.

Patient Guides

Tirzepatide Dosing Guide: Complete Titration Schedule, Adjustments & What to Expect

Q: How long does tirzepatide take to work?

Most patients notice appetite suppression within 2–4 weeks. Meaningful weight loss begins at the 5mg dose (weeks 5–8). The SURMOUNT-1 trial showed weight loss continued progressively through 72 weeks, so results build over many months of treatment.

Q: Do I need to reach the maximum 15mg tirzepatide dose?

No. There is no clinical obligation to reach 15mg. The 5mg dose produced ~15% weight loss in trials — a clinically meaningful result. If you're achieving your goals at 7.5mg or 10mg with manageable side effects, staying at that dose is appropriate.

Sarah ChenLead Health Editor

Reviewed by Dr. James Okafor, PharmDPharmD

Updated March 28, 2026

Fact Checked

Complete tirzepatide dosing guide covering the FDA titration schedule for Mounjaro and Zepbound, compounded dosing, side effect management, missed doses, and what to expect at each dose level.

Key Takeaways

FDA titration: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg over 20 weeks, 4 weeks per step.
5mg tirzepatide alone produced ~15% weight loss at 72 weeks — no clinical requirement to reach 15mg.
Missed dose window: take within 4 days; if >4 days past, skip and resume regular schedule.
SURMOUNT-4: patients who stopped tirzepatide regained ~two-thirds of lost weight over 52 weeks.
Tirzepatide can be stored at room temperature for up to 14 days if refrigeration is unavailable.

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Tirzepatide Dosing Guide: Complete Titration Schedule, Adjustments & What to Expect

Updated April 2026: Timestamp refresh. No major clinical dosing changes. Added Wegovy HD (7.2mg) context in comparison table. Updated compounded tirzepatide availability (supply <3% of peak following 2026 regulatory enforcement).

Tirzepatide is the first dual GIP/GLP-1 receptor agonist approved for weight loss and type 2 diabetes in the US. It works on two incretin pathways simultaneously — a mechanism that produced the largest weight loss results of any injectable medication in clinical trials.

This guide covers everything about tirzepatide dosing: the FDA-approved titration schedule for both Mounjaro and Zepbound, compounded tirzepatide options, what to expect at each dose level, side effect management, missed dose protocols, and how tirzepatide dosing compares to semaglutide. Whether you're starting tirzepatide or adjusting your dose, this is the reference you need.

What Is Tirzepatide?

Tirzepatide is a once-weekly injectable medication that activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. This dual mechanism distinguishes it from semaglutide, which targets GLP-1 alone.

It's sold under two brand names:

Brand	FDA Indication	Notes
Mounjaro	Type 2 diabetes	First approved May 2022
Zepbound	Chronic weight management (obesity/overweight)	Approved November 2023

Mounjaro and Zepbound contain the same molecule at the same doses. The difference is the label — your prescriber chooses based on your diagnosis and insurance situation. The dosing schedule is identical for both.

FDA-Approved Titration Schedule

Tirzepatide uses a slower titration than semaglutide, with six dose levels instead of five. The schedule is designed to minimize gastrointestinal side effects by increasing the dose gradually over 20 weeks.

Phase	Weeks	Weekly Dose	Purpose & What to Expect
Step 1	1-4	2.5 mg	Starting dose. Not intended to be therapeutic — this step exists purely for tolerability. Most patients notice minimal appetite changes. Side effects are mild if present at all.
Step 2	5-8	5 mg	First therapeutic dose. Appetite suppression becomes noticeable. This is the first dose where meaningful weight loss begins. GI side effects are most common during this transition.
Step 3	9-12	7.5 mg	Intermediate dose. Appetite suppression strengthens. Many patients find this to be a comfortable long-term dose with good results and manageable side effects.
Step 4	13-16	10 mg	Higher therapeutic dose. Significant appetite reduction. Weight loss accelerates for most patients. Food noise is substantially quieter.
Step 5	17-20	12.5 mg	Second-highest dose. Strong efficacy. Some patients stay here if 15 mg side effects are not tolerable.
Step 6	21+	15 mg	Maximum FDA-approved dose. Highest efficacy in clinical trials. Not every patient needs to reach this level.

Total ramp-up: 20 weeks (5 months) from first injection to maximum dose. For a Mounjaro-specific quick-reference dose chart including missed dose rules and pen timing, see our Mounjaro dose guide.

Maintenance dose range: 5 mg to 15 mg. Your maintenance dose is whichever dose achieves your target outcomes with tolerable side effects. There is no clinical obligation to reach 15 mg — if you're responding well at 7.5 mg or 10 mg, staying there is a valid long-term approach. Discuss this with your prescriber.

Understanding the 4-Week Steps

Each dose level lasts a minimum of 4 weeks. This is not arbitrary. It takes approximately 4-5 weeks for tirzepatide to reach steady-state blood levels at any given dose. Increasing sooner means your body hasn't fully adjusted, which increases the risk of GI side effects without improving efficacy.

Your prescriber may keep you at any dose level for longer than 4 weeks if:

You're losing weight steadily and tolerating the dose well
Side effects haven't resolved and need more time to settle
You're meeting clinical targets without needing a higher dose

Compounded Tirzepatide Dosing

April 2026 note: Compounded tirzepatide availability has dropped significantly following FDA enforcement action, manufacturer lawsuits, and the resolution of the tirzepatide drug shortage. Supply is severely limited compared to its 2024-2025 peak. Most major telehealth providers (including Hims) have exited compounded tirzepatide entirely. The information below is retained for patients still on compounded tirzepatide through remaining 503A pharmacies.

Compounded tirzepatide is prepared by 503A (patient-specific) or 503B (outsourcing facility) compounding pharmacies. These products are not FDA-approved.

Why Compounded Dosing Differs

Compounding pharmacies can prepare tirzepatide at intermediate doses not available in the branded pens. This allows for a more gradual titration, which some patients and prescribers prefer — particularly for patients who experienced significant GI side effects on branded tirzepatide's standard dose jumps.

Typical Compounded Titration Schedule

Phase	Weekly Dose	Duration	Notes
Step 1	2.5 mg	4 weeks	Same as branded starting dose
Step 1.5	3 mg	2-4 weeks	Intermediate step not available in branded pens
Step 2	5 mg	4 weeks	First therapeutic dose
Step 2.5	6 mg	2-4 weeks	Eases the 5 mg to 7.5 mg jump
Step 3	7.5 mg	4 weeks	Mid-range therapeutic
Step 4	10 mg	4 weeks	Higher therapeutic dose
Step 5	12.5 mg	4 weeks	Second-highest dose
Step 6	15 mg	Ongoing	Maximum studied dose

The intermediate steps (3 mg, 6 mg, 8 mg) are the primary advantage of compounded tirzepatide. For patients who struggled with GI side effects on the 2.5 mg to 5 mg jump or the 5 mg to 7.5 mg jump, these half-steps can make the difference between tolerating the medication and discontinuing it.

Important Compounded Tirzepatide Considerations

Vial and syringe. Compounded tirzepatide typically comes in multi-dose vials. You'll draw up each dose using an insulin syringe. This requires careful attention to concentration and volume.
Concentration varies. Different pharmacies compound at different concentrations. Always verify your vial's concentration (mg/mL) and calculate the correct injection volume for your prescribed dose.
Doses above 15 mg are not FDA-studied. Some compounding providers may offer doses above 15 mg. There is no clinical trial data supporting the safety or efficacy of supratherapeutic doses. Discuss the risk-benefit carefully with your prescriber.
No bioequivalence data. Compounded tirzepatide has not been studied head-to-head against Mounjaro or Zepbound. Absorption and efficacy may differ.

What to Expect at Each Dose Level

2.5 mg (Weeks 1-4)

This is purely a tolerability dose. The clinical trials did not study 2.5 mg as a maintenance dose because it doesn't produce meaningful weight loss on its own.

Appetite: Minimal change for most patients. Some notice slight reduction in hunger.
Weight loss: Little to none. Do not be discouraged — the medication hasn't reached therapeutic levels yet.
Side effects: Mild if present. Approximately 15% of patients experience some nausea; about 10% report diarrhea. Most symptoms resolve within the first 1-2 weeks.
What to do: Focus on establishing your injection routine and building the habit. Start hydration and nutrition habits now.

5 mg (Weeks 5-8)

The first dose where tirzepatide starts working therapeutically. This is where most patients first feel the medication's effects.

Appetite: Noticeably reduced. Portions naturally decrease. Many patients describe a quieting of "food noise."
Weight loss: Begins in earnest. The SURMOUNT-1 trial showed approximately 15% body weight loss at 5 mg over 72 weeks.
Side effects: GI effects are most common during this transition. Approximately 25% of patients experience nausea. Constipation, diarrhea, and decreased appetite are also reported. Symptoms typically peak in the first week at the new dose and improve over 2-3 weeks.
What to do: Eat smaller, more frequent meals. Prioritize protein (aim for 60+ grams/day). Stay hydrated. Avoid high-fat and fried foods, which tend to worsen nausea.

7.5 mg (Weeks 9-12)

An intermediate dose that many patients find to be a strong balance of efficacy and tolerability.

Appetite: Significantly suppressed. Patients commonly report forgetting to eat or feeling full very quickly.
Weight loss: Accelerating. This dose sits between the two highest-studied doses and represents a meaningful therapeutic level.
Side effects: Moderate for most patients. GI symptoms from the dose increase typically resolve within 2 weeks. Some patients experience fatigue during the transition.
What to do: Track nutrition carefully. At this level of appetite suppression, undereating becomes a real risk. Ensure adequate protein and caloric intake. Light resistance training helps preserve muscle mass during rapid weight loss.

10 mg (Weeks 13-16)

Strong therapeutic dose. The SURMOUNT-1 trial's 10 mg arm showed approximately 19.5% average body weight loss at 72 weeks.

Appetite: Profoundly reduced. Caloric intake may drop 30-40% from baseline without conscious effort.
Weight loss: Substantial and ongoing. Most patients are well into significant weight loss territory by this point.
Side effects: Variable. Patients who tolerated 7.5 mg well often handle this transition smoothly. New GI symptoms are less common at this stage but can occur.
What to do: Prioritize nutrition quality over quantity. Consider a multivitamin if caloric intake drops below 1,200 calories/day. Monitor for signs of dehydration and ensure 64+ oz of water daily.

12.5-15 mg (Weeks 17+)

Maximum dosing range. The 15 mg dose in SURMOUNT-1 produced approximately 20.9% average body weight loss at 72 weeks — the highest weight loss ever recorded for a non-surgical intervention at the time of publication.

Appetite: Maximum suppression. Some patients report near-complete absence of hunger signals.
Weight loss: Peak efficacy, though the incremental benefit of 15 mg over 10 mg varies widely between individuals.
Side effects: Highly individual. Some patients tolerate 15 mg without significant issues; others find the GI effects at this level unmanageable. There is no shame in stepping back to 10 mg or 12.5 mg if quality of life is impaired.
What to do: This is where the lowest effective dose principle matters most. If you achieved your goals at 10 mg, discuss with your prescriber whether the additional benefit of 15 mg justifies any additional side effects.

Side Effects by Dose Level

Side Effect	2.5 mg	5 mg	7.5 mg	10 mg	12.5-15 mg
Nausea	~15%	~25%	~20%	~18%	~15-20%
Diarrhea	~10%	~15%	~15%	~14%	~12%
Constipation	~5%	~10%	~10%	~10%	~10%
Decreased appetite	~5%	~15%	~20%	~25%	~25%
Vomiting	~3%	~8%	~7%	~6%	~6%
Injection site reaction	~3%	~3%	~3%	~3%	~3%

Note: Side effects are most pronounced during the first 1-2 weeks after each dose increase, then typically improve. Percentages are approximate and drawn from pooled SURMOUNT trial data. Your individual experience may differ substantially.

Managing GI Side Effects

The most common side effects — nausea, diarrhea, constipation, and vomiting — are dose-related and typically transient. Strategies that help:

Eat smaller meals, more frequently. Five small meals beats three large ones while adjusting.
Avoid trigger foods. Fried, greasy, very sweet, and very spicy foods tend to worsen nausea.
Stay hydrated. Dehydration worsens nausea and constipation. Aim for 80+ oz of water daily.
Ginger or peppermint. Ginger tea, ginger chews, or peppermint can help mild nausea.
Fiber for constipation. If constipation develops, increase fiber gradually and consider a stool softener (discuss with your prescriber).
Timing. Some patients find side effects milder if they inject in the evening rather than the morning. Experiment to find what works for you.

If GI side effects persist beyond 2-3 weeks at a given dose or are severe enough to affect your ability to eat or drink, contact your prescriber. Dose reduction or a longer stay at your current dose may be warranted.

Injection Instructions

Tirzepatide is administered as a subcutaneous injection once weekly. Both Mounjaro and Zepbound come as pre-filled, single-dose auto-injector pens — you do not need to draw up a dose or handle vials (unless using compounded tirzepatide).

Where to Inject

Abdomen: At least 2 inches away from the navel. Avoid the waistline area.
Front of thigh: Middle third of the thigh, avoiding the knee.
Back of upper arm: Only if someone else is administering the injection (it's difficult to reach yourself).

Injection Best Practices

Rotate injection sites. Do not inject in the same spot repeatedly. Rotate between abdomen, thighs, and arms. Within each area, move at least 1 inch from the previous injection site.
Room temperature. Remove the pen from the refrigerator 30 minutes before injecting. Cold medication can be more uncomfortable.
Clean the area. Wipe the injection site with an alcohol swab and let it dry.
Do not rub. After injecting, do not rub the site. Light pressure with a cotton ball is fine if there's minor bleeding.
Same day each week. Pick a day and stick to it. The medication works best with consistent weekly dosing.
Any time of day. There is no clinical requirement to inject in the morning or evening. Choose whatever time is easiest to remember.

Changing Your Injection Day

You can change the day of the week you inject, but the last dose must have been at least 3 days (72 hours) prior. For example, if you normally inject on Mondays but want to switch to Thursdays, take your Monday dose, then your next dose on Thursday — that's 3 days apart, which meets the minimum requirement.

Missed Dose Protocol

Life happens. Here's what to do:

If within 4 days (96 hours) of the missed dose: Take it as soon as you remember. Then resume your regular weekly schedule.
If more than 4 days have passed: Skip the missed dose entirely. Take your next dose on the regularly scheduled day.
Never take two doses within 3 days of each other. Doubling up dramatically increases the risk of severe GI side effects and is not safe.

If you miss multiple consecutive doses, contact your prescriber. Depending on how long the gap was, you may need to restart at a lower dose to re-establish tolerability.

Storage

Brand Pens (Mounjaro and Zepbound)

Before first use: Store in the refrigerator at 36°F-46°F (2°C-8°C).
Room temperature: Pens can be stored at room temperature (up to 86°F / 30°C) for up to 14 days.
Do not freeze. If a pen has been frozen, discard it.
Protect from light. Store in original carton until ready to use.
After use: Dispose of the used pen in a sharps container.

Compounded Tirzepatide (Vials)

Storage requirements vary by pharmacy and formulation. Follow the specific instructions provided by your compounding pharmacy.
Most compounded tirzepatide vials require refrigeration and have a beyond-use date (typically 30-90 days).
Once punctured, multi-dose vials have a shorter shelf life. Track the date you first used each vial.

When to Contact Your Doctor

Reach out to your prescriber promptly if you experience:

Severe abdominal pain that doesn't resolve, especially if it radiates to your back (possible pancreatitis)
Persistent vomiting lasting more than 24 hours or preventing you from keeping fluids down
Signs of dehydration — dark urine, dizziness, rapid heartbeat, dry mouth
Allergic reaction symptoms — rash, itching, swelling of face/lips/tongue, difficulty breathing
Vision changes — particularly if you have diabetes (rapid blood sugar improvement can temporarily worsen diabetic retinopathy)
A lump or swelling in your neck, hoarseness, or difficulty swallowing (thyroid-related concern)
Symptoms of gallbladder problems — pain in the upper right abdomen, fever, jaundice

Important Safety Warnings

Do not use tirzepatide with other GLP-1 receptor agonist medications (such as semaglutide, liraglutide, or dulaglutide). Using two GLP-1 pathway drugs simultaneously increases the risk of severe side effects without established benefit.
Thyroid cancer risk. Tirzepatide carries a boxed warning regarding thyroid C-cell tumors observed in animal studies. It is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2).
Pancreatitis. Cases of acute pancreatitis have been reported. If you have a history of pancreatitis, discuss the risks carefully with your prescriber.
Oral contraceptives. Tirzepatide may reduce the effectiveness of oral birth control pills, particularly during the first 4 weeks of treatment and for 4 weeks after each dose increase. The medication slows gastric emptying, which can affect absorption of oral medications. Use a backup contraceptive method (such as condoms) or discuss switching to a non-oral contraceptive with your prescriber during these periods.
Hypoglycemia. If you take insulin or sulfonylureas for diabetes, your prescriber may need to reduce those doses when starting tirzepatide to avoid low blood sugar.

Tirzepatide vs Semaglutide Dosing Comparison

These are the two most prescribed GLP-1 medications for weight loss. Here's how their dosing compares:

Factor	Tirzepatide (Zepbound/Mounjaro)	Semaglutide (Wegovy)	Semaglutide (Wegovy HD)
Mechanism	Dual GIP/GLP-1 agonist	GLP-1 agonist only	GLP-1 agonist only
Starting dose	2.5 mg weekly	0.25 mg weekly	Same titration as Wegovy
Dose steps	6 (2.5, 5, 7.5, 10, 12.5, 15 mg)	5 (0.25, 0.5, 1.0, 1.7, 2.4 mg)	7 steps (to 7.2 mg over 28 wk)
Maximum dose	15 mg	2.4 mg	7.2 mg
Time to max dose	20 weeks	16 weeks	28 weeks
Maintenance range	5-15 mg	1.7-2.4 mg	3.6-7.2 mg
Injection frequency	Weekly	Weekly	Weekly
Average weight loss (trials)	~20.9% at 15 mg (72 wk)	~15% at 2.4 mg (68 wk)	~20.7% at 7.2 mg (STEP UP)
Missed dose window	4 days	5 days	5 days
Oral formulation available	No	Yes (oral Wegovy)	No
Notable side effect	GI side effects	GI side effects	Dysesthesia (18.9%)

Key Differences in Practice

More dose options. Tirzepatide has six dose levels versus semaglutide's five, allowing slightly more flexibility in finding your optimal dose.
Greater average weight loss. Head-to-head, tirzepatide produced more weight loss across all dose levels in clinical trials. However, individual responses vary — some patients respond better to semaglutide.
Different side effect profile. Both cause GI side effects, but the pattern and severity can differ. Some patients who couldn't tolerate one medication do well on the other.
Longer titration. Tirzepatide takes 20 weeks to reach maximum dose versus 16 weeks for semaglutide. The more gradual increase may contribute to better GI tolerability.
No oral option. As of April 2026, there is no oral tirzepatide formulation approved for weight loss. Oral Wegovy is available, and orforglipron (daily pill, $149/month announced) is awaiting FDA approval (PDUFA April 10, 2026) for patients who prefer tablets over injections. See our oral GLP-1 pill comparison for details.

Frequently Asked Questions

How long does tirzepatide take to work?

Most patients notice appetite suppression within the first 2-4 weeks, though it's usually mild at the 2.5 mg starting dose. Meaningful weight loss — the kind you can see on the scale consistently — typically begins at the 5 mg dose (weeks 5-8). The SURMOUNT-1 trial showed weight loss continued progressively through 72 weeks. Tirzepatide is not a quick fix; it's a long-term treatment that produces results over months. For a full comparison of timelines across medications, see our guide to how long Ozempic, Wegovy & tirzepatide take to work.

Can I titrate faster than the standard schedule?

Some prescribers offer accelerated titration, but there's no evidence that reaching 15 mg faster produces better long-term outcomes. Faster titration substantially increases the risk of GI side effects, which can lead to dehydration, poor nutrition, and medication discontinuation. The 4-week steps were designed based on clinical trial data across thousands of participants. Unless your prescriber has a specific clinical reason, following the standard schedule is safer.

What if I can't tolerate the higher doses?

Not every patient needs or can tolerate 15 mg. The 5 mg dose produced ~15% weight loss in trials — a clinically meaningful result. If you're achieving your goals at 5 mg, 7.5 mg, or 10 mg with manageable side effects, staying at that dose is appropriate. Discuss the lowest effective dose approach with your prescriber.

Can I switch from semaglutide to tirzepatide?

Yes, but there is no direct dose conversion between the two medications. Your prescriber will typically start tirzepatide from 2.5 mg regardless of your semaglutide dose, since tirzepatide activates different receptors and the GI tolerability profile differs. Some prescribers may move through the early steps more quickly for patients who tolerated semaglutide well, but this is at their clinical discretion.

Is tirzepatide safe long-term?

Tirzepatide has been studied for up to 72 weeks in the SURMOUNT trials and for 104 weeks in diabetes trials (SURPASS program). Long-term safety data continues to accumulate through 2027. The SURPASS-CVOT cardiovascular outcomes trial is ongoing. The medication carries the same thyroid C-cell tumor boxed warning as other GLP-1 class drugs, based on animal data — over 9 years of human post-market data for the GLP-1 class has not confirmed this risk. Discuss the evolving safety data with your prescriber, particularly if you plan to use tirzepatide indefinitely.

Do I need lab work while on tirzepatide?

Most prescribers recommend baseline labs before starting — typically a comprehensive metabolic panel, A1c, and lipid panel. Periodic monitoring (every 3-6 months) is standard practice, especially for patients with diabetes, kidney disease, or liver conditions. Some telehealth providers include lab work in their programs; others require labs through your primary care provider. If you have type 2 diabetes, more frequent glucose monitoring is important during titration as your insulin needs may change.

What happens if I stop taking tirzepatide?

The SURMOUNT-4 trial examined this directly. Patients who switched from tirzepatide to placebo after 36 weeks regained approximately two-thirds of their lost weight over the following 52 weeks. This is consistent with the understanding that obesity is a chronic condition requiring ongoing treatment. If you're considering stopping, discuss a gradual dose-reduction plan with your prescriber rather than stopping abruptly.

Will tirzepatide interact with my other medications?

Tirzepatide slows gastric emptying, which can affect the absorption of some oral medications. This is most relevant for oral contraceptives (see safety warnings above) and medications with narrow therapeutic windows. Inform your prescriber about all medications you take, including over-the-counter drugs and supplements. Timing adjustments may be needed for certain medications.

For a step-by-step walkthrough of getting tirzepatide prescribed online, including provider comparison and pricing, see our How to Get Tirzepatide Online guide. For the Mounjaro-specific dose chart and titration schedule, see our Mounjaro Dose Guide.

This guide is for informational purposes only and does not constitute medical advice. Tirzepatide dosing should always be directed by a qualified healthcare provider based on your individual health status, goals, and tolerability. Do not adjust your dose without medical guidance. Clinical trial results represent averages — individual weight loss and side effect experiences vary. Last updated April 2026.

Sarah Chen

Lead Health Editor

Sarah covers telehealth and digital health access. She has spent 8 years in health journalism, previously writing for health policy publications. She leads editorial at Telehealth Ally.

Medically Reviewed By

Dr. James Okafor, PharmD

Dr. Okafor is a licensed pharmacist who reviews medication guides and dosing content for clinical accuracy. He has 12 years of experience in clinical pharmacy.

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Tirzepatide Dosing Guide: Complete Titration Schedule, Adjustments & What to Expect

Key Takeaways

Tirzepatide Dosing Guide: Complete Titration Schedule, Adjustments & What to Expect

What Is Tirzepatide?

FDA-Approved Titration Schedule

Understanding the 4-Week Steps

Compounded Tirzepatide Dosing

Why Compounded Dosing Differs

Typical Compounded Titration Schedule

Important Compounded Tirzepatide Considerations

What to Expect at Each Dose Level

2.5 mg (Weeks 1-4)

5 mg (Weeks 5-8)

7.5 mg (Weeks 9-12)

10 mg (Weeks 13-16)

12.5-15 mg (Weeks 17+)

Side Effects by Dose Level

Managing GI Side Effects

Injection Instructions

Where to Inject

Injection Best Practices

Changing Your Injection Day

Missed Dose Protocol

Storage

Brand Pens (Mounjaro and Zepbound)

Compounded Tirzepatide (Vials)

When to Contact Your Doctor

Important Safety Warnings

Tirzepatide vs Semaglutide Dosing Comparison

Key Differences in Practice

Frequently Asked Questions

How long does tirzepatide take to work?

Can I titrate faster than the standard schedule?

What if I can't tolerate the higher doses?

Can I switch from semaglutide to tirzepatide?

Is tirzepatide safe long-term?

Do I need lab work while on tirzepatide?

What happens if I stop taking tirzepatide?

Will tirzepatide interact with my other medications?

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