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Calibrate vs Sesame

A detailed head-to-head comparison of Calibrate and Sesame — pricing, peptides, consultation models, and patient reviews.

At a Glance

Rating★★★★☆ 4.0/5
Starting Price$299/mo
Peptides3
ConsultationVideo Telehealth
Lab TestingYes
Shipping3-5 business days

Pros

  • Comprehensive metabolic health program (not just medication)
  • Lab testing and metabolic panels included
  • Video consultations with obesity medicine specialists
  • Works with insurance to cover GLP-1 medication costs
  • Focus on sustainable weight loss and metabolic reset

Cons

  • Higher program cost ($299/mo for coaching + medication separate)
  • One-year commitment required
  • Insurance coverage for medication not guaranteed
  • Not available in all states
RatingNo reviews
Starting PriceN/A
Peptides2
ConsultationAsync Telehealth
Lab TestingYes
Shipping3-5 business days

Pros

  • No subscription, no membership required, no recurring charges
  • Lowest consultation cost in the market ($29-$79 per visit)
  • Full control over where you fill your prescription
  • Orforglipron and Wegovy HD available alongside other branded options
  • Broadest medication options
  • No long-term commitment

Cons

  • You handle medication sourcing, insurance navigation, and pharmacy selection yourself
  • No prior authorization assistance
  • No coaching, behavioral support, or structured program
  • No lab testing included or coordinated
  • Clinician quality varies across the marketplace (independent providers, not Sesame employees)
  • No ongoing care coordination between visits

Pros & Cons

Peptide Pricing Comparison

PeptideCalibrateSesame
Liraglutide
$299/monthly
Not offered
Semaglutide
$299/monthly
Price unavailable
Tirzepatide
$299/monthly
Price unavailable

Frequently Asked Questions

Is Calibrate or Sesame better?

Calibrate offers 3 peptides with a 4/5 rating and video telehealth consultations. Sesame offers 2 peptides and async telehealth consultations. The best choice depends on which peptides you need, your budget, and preferred consultation model.

Which is cheaper, Calibrate or Sesame?

See the pricing table above for a detailed comparison.