Knownwell vs Sesame
A detailed head-to-head comparison of Knownwell and Sesame — pricing, peptides, consultation models, and patient reviews.
At a Glance
RatingNo reviews
Starting PriceN/A
Peptides2
ConsultationHybrid
Lab TestingNo
Shipping3-5 business days
Pros
- Board-certified obesity medicine physicians provide a level of clinical specialization not available on most telehealth platforms
- Hybrid model allows in-person examination for complex cases, medication intolerance evaluation, and physical assessment
- Insurance-accepted model reduces out-of-pocket costs compared to cash-pay competitors
- Full GLP-1 formulary including brand-name Wegovy and Zepbound, insulating patients from compounding supply disruptions
- Prior authorization support included
- Appropriate for patients with significant comorbidities (T2D, hypertension, sleep apnea) who need specialist-level management
Cons
- Geographic availability is limited to select Northeast markets; not a national platform as of March 2026
- Insurance-based model means access depends on plan participation and prior authorization approval
- Not the fastest or cheapest path to a GLP-1 prescription for patients who simply want access and have no comorbidities
- In-person visit requirement (when clinically appropriate) is a barrier for patients who cannot travel to a clinic
- Limited public information on cash-pay pricing for patients without covered insurance
RatingNo reviews
Starting PriceN/A
Peptides2
ConsultationAsync Telehealth
Lab TestingYes
Shipping3-5 business days
Pros
- No subscription, no membership required, no recurring charges
- Lowest consultation cost in the market ($29-$79 per visit)
- Full control over where you fill your prescription
- Orforglipron and Wegovy HD available alongside other branded options
- Broadest medication options
- No long-term commitment
Cons
- You handle medication sourcing, insurance navigation, and pharmacy selection yourself
- No prior authorization assistance
- No coaching, behavioral support, or structured program
- No lab testing included or coordinated
- Clinician quality varies across the marketplace (independent providers, not Sesame employees)
- No ongoing care coordination between visits
Pros & Cons
Peptide Pricing Comparison
| Peptide | Knownwell | Sesame |
|---|---|---|
| Semaglutide | Price unavailable | Price unavailable |
| Tirzepatide | Price unavailable | Price unavailable |
Frequently Asked Questions
Is Knownwell or Sesame better?
Knownwell offers 2 peptides and hybrid consultations. Sesame offers 2 peptides and async telehealth consultations. The best choice depends on which peptides you need, your budget, and preferred consultation model.
Which is cheaper, Knownwell or Sesame?
See the pricing table above for a detailed comparison.