Defy Medical vs Knownwell
A detailed head-to-head comparison of Defy Medical and Knownwell — pricing, peptides, consultation models, and patient reviews.
At a Glance
Rating★★★★☆ 4.1/5
Starting Price$120/mo
Peptides32
ConsultationVideo Telehealth
Lab TestingYes
Shipping3-5 business days
Pros
- Longest-running telehealth peptide provider
- Wide peptide and hormone catalog
- Video consultations with experienced physicians
- Comprehensive lab panels included
Cons
- Higher initial consultation fee (~$250)
- Separate lab and medication costs
- Not the cheapest per-medication pricing
RatingNo reviews
Starting PriceN/A
Peptides2
ConsultationHybrid
Lab TestingNo
Shipping3-5 business days
Pros
- Board-certified obesity medicine physicians provide a level of clinical specialization not available on most telehealth platforms
- Hybrid model allows in-person examination for complex cases, medication intolerance evaluation, and physical assessment
- Insurance-accepted model reduces out-of-pocket costs compared to cash-pay competitors
- Full GLP-1 formulary including brand-name Wegovy and Zepbound, insulating patients from compounding supply disruptions
- Prior authorization support included
- Appropriate for patients with significant comorbidities (T2D, hypertension, sleep apnea) who need specialist-level management
Cons
- Geographic availability is limited to select Northeast markets; not a national platform as of March 2026
- Insurance-based model means access depends on plan participation and prior authorization approval
- Not the fastest or cheapest path to a GLP-1 prescription for patients who simply want access and have no comorbidities
- In-person visit requirement (when clinically appropriate) is a barrier for patients who cannot travel to a clinic
- Limited public information on cash-pay pricing for patients without covered insurance
Pros & Cons
Peptide Pricing Comparison
| Peptide | Defy Medical | Knownwell |
|---|---|---|
| AOD-9604 | $160/monthly | Not offered |
| BPC-157 | $165/monthly | Not offered |
| CJC-1295 / Ipamorelin | $180/monthly | Not offered |
| Dihexa | $200/monthly | Not offered |
| Epithalon | $250/per-cycle | Not offered |
| FOXO4-DRI | $450/per-cycle | Not offered |
| GHK-Cu | $145/monthly | Not offered |
| GHRP-2 | $150/monthly | Not offered |
| GHRP-6 | $150/monthly | Not offered |
| Gonadorelin | $140/monthly | Not offered |
| IGF-1 LR3 | $250/monthly | Not offered |
| Kisspeptin | $200/monthly | Not offered |
| KPV | $130/monthly | Not offered |
| Liraglutide | $220/monthly | Not offered |
| LL-37 | $180/monthly | Not offered |
| Melanotan II | $120/per-vial | Not offered |
| MK-677 | $120/monthly | Not offered |
| MOTS-c | $220/monthly | Not offered |
| NAD+ | $220/monthly | Not offered |
| Oxytocin | $120/monthly | Not offered |
| P21 | $180/monthly | Not offered |
| Pentadeca Arginate | $175/monthly | Not offered |
| PT-141 | $150/per-vial | Not offered |
| Retatrutide | $450/monthly | Not offered |
| Selank | $120/monthly | Not offered |
| Semaglutide | $280/monthly | Price unavailable |
| Semax | $120/monthly | Not offered |
| Sermorelin | $175/monthly | Not offered |
| SS-31 | $280/monthly | Not offered |
| TB-500 | $180/monthly | Not offered |
| Tesamorelin | $350/monthly | Not offered |
| Thymosin Alpha-1 | $220/monthly | Not offered |
| Tirzepatide | Not offered | Price unavailable |
Frequently Asked Questions
Is Defy Medical or Knownwell better?
Defy Medical offers 32 peptides with a 4.1/5 rating and video telehealth consultations. Knownwell offers 2 peptides and hybrid consultations. The best choice depends on which peptides you need, your budget, and preferred consultation model.
Which is cheaper, Defy Medical or Knownwell?
See the pricing table above for a detailed comparison.